Agilent – Quadrupole Time of Flight (Q-TOF) LC/MS – 6545, 6545XT, 6560, 6500 Series, 6530, 6550
Extensive Portfolio of LC/MS Instruments
Agilent’s portfolio of LC/MS instruments takes the versatility of HPLC separation to another level with the sensitivity and specificity of mass spectrometry.
Add easy-to-use mass selective detection to your HPLC analyses with single quadrupole (SQ) LC/MSD. Achieve quantitative precision with triple quadrupole (TQ) systems that break sensitivity and size barriers. Go untargeted and see more while identifying unknowns using time-of-flight (TOF/Q-TOF) technology that delivers simultaneous accuracy, speed, and isotopic fidelity. The reliable family of Agilent LC/MS instruments provides a range of capability and performance to solve any LC/MS analysis challenge.
Available Models
The Agilent 6545XT AdvanceBio LC/Q-TOF system is designed to handle multiple workflows in biopharmaceutical characterization. When you need to access the most information at the intact protein level, automatically confirm a sequence through peptide mapping, and confidently understand PTMs, Agilent provides a UHPLC Q-TOF that delivers.
Accurately profile major and minor proteoforms with time-of-flight technology offering new levels of sensitivity and clarity to intact protein mass spectrometry. Easily dig deeper into peptide digests with the Iterative MS/MS mode of operation. The 6545XT AdvanceBio Q-TOF is the analytical cornerstone in a comprehensive set of tools designed for biopharma.
Key Features
- Get up and running fast with quick-start methods that include Agilent AdvanceBio LC columns for intact protein and peptide workflows.
- Characterize both major and minor intact protein variations with an automated data workflow featuring MassHunter BioConfirm software.
- Adapt your instrument to your needs with SWARM autotune to ensure optimum performance with no manual adjustment. New large molecule setting provides sub-nanogram detection levels for intact glycosylated monoclonal antibodies.
- Be sure of your results with mass accuracies within 10 ppm for glycosylated intact proteins.
- Dig deeper into your digested samples with the powerful new iterative MS/MS feature.
- Maximize your uptime with a system tested to perform through thousands of protein injections without degradation of performance.
- Minimize maintenance delays with vent-free cleaning of entrance optics.
The Agilent 6560 Ion Mobility Q-TOF LC/MS system delivers unrivaled separation and selectivity by combining chromatography, ion mobility, and mass spectrometry. The 6560 Q-TOF mass spectrometer can even uncover structural information that cannot be seen with traditional high-resolution LC/MS systems.
The system features innovative electrodynamic ion funnel technology to dramatically improve sensitivity while maintaining an attractive low field drift tube design. This allows you to directly calculate collision cross sections (CCS) and preserve labile targets. Whether you are looking to create a more comprehensive profile of metabolomics samples, characterize complex polymeric mixtures, or understand structural changes in biomolecules, ion mobility provides access to new information.
Key Features
- The gold standard in direct collision cross section measurement and accuracy
- Achieve the utmost in separation capacity by combining UHPLC, ion mobility, and high resolution mass spectrometry
- Better separation of complex isobaric classes such as lipids and glycans
- In-depth characterization of structural conformations and isomeric compounds
- Low energy drift tube design to conserve structural fidelity of molecules in the gas phase
Raise your analysis to a new level with the Agilent 6530 Quadrupole Time-of-Flight LC/MS system. The 6530 delivers the power of high-resolution, accurate-mass MS/MS, so you can be fully confident of your data.
Key Features
- Mass accuracy within 2 ppm gives you complete confidence in your analysis.
- Powerful Agilent Jet Stream source enables you to uncover low level components.
- Wide in-spectrum dynamic range facilitates simultaneous measurement of minor components in the presence of intense background interferences.
- The latest developments in Agilent Infinity II UHPLC, 2D-LC, SFC, and even GC-APCI chromatographic interfaces give you blazing fast acquisition speed.
- Powerful MassHunter software provides the latest software capabilities for profiling, characterizing, identifying, and quantifying compounds in complex mixtures via high-definition MS and MS/MS.
- Check out the latest developments in untargeted screening and quantitation using Agilent’s All Ions MS/MS technique.
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Brand
Agilent is a leader in life sciences, diagnostics and applied chemical markets. The company provides laboratories worldwide with instruments, services, consumables, applications and expertise, enabling customers to gain the insights they seek. Agilent’s expertise and trusted collaboration give them the highest confidence in our solutions.